Iron overload in beta thalassemia major patients

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Endocrine Dysfunctions in Iron Overload in Patients with Major Thalassemia

Abstract Background The aim of the present study was to determine the endocrine dysfunction in patients with major thalassemia, who receive hyper transfusion. Materials and Methods This cross sectional study was performed during one year, which included 65 major thalassemia patients (31 females and 34 males), aged between 14 month to 27 years old (median 10,3). Growth assessment was measur...

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Correlation between QRS Complex Changes and Cardiac Iron Overload in Beta Thalassemia Major Patients Using T2*MRI

Background and purpose: Cardiac magnetic resonance imaging (MRI) is a costly method to assess cardiac iron overload. The presence of fragmented QRS (fQRS) indicates changes due to iron overload in cardiac tissue. The aim of this study was to evaluate the correlation between fQRS and cardiac iron overload using cardiac MRI in patients with β-thalassemia major (β-TM). Materials and methods: This...

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endocrine dysfunctions in iron overload in patients with major thalassemia

abstract background the aim of the present study was to determine the endocrine dysfunction in patients with major thalassemia, who receive hyper transfusion. materials and methods this cross sectional study was performed during one year, which included 65 major thalassemia patients (31 females and 34 males), aged between 14 month to 27 years old (median 10,3). growth assessment was measured by...

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IRON OVERLOAD IN BETA THALASSEMIA – A Review

Due to improvements in transfusion therapy in beta-thalassemia major patients, transfusional hemosiderosis has now become the major cause of late morbidity and mortality in them. In India and other developing countries, iron chelation therapy is still not strictly adhered to in these children, mostly due to financial constraints. An orally effective and cheap iron chelator is the need of the ho...

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Dual-echo TFE MRI for the assessment of myocardial iron overload in beta-thalassemia major patients.

PURPOSE Cardiac failure due to myocardial iron overload is the most common cause of death in beta-thalassemia patients. Multi/ two echo times-turbo field echo (TE-TFE) magnetic resonance imaging (MRI) is considered the gold standard technique in the evaluation of myocardial iron accumulation. However, multi TE-TFE technique is not available in all scanners. The aim of our study was to show the ...

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ژورنال

عنوان ژورنال: International Journal of Blood transfusion and Immunohematology

سال: 2017

ISSN: 2230-9020

DOI: 10.5348/ijbti-2017-32-oa-5